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DMSO

What You Need To Know About Dimethyl Sulfoxide (DMSO) – 10 Surprising Health and Therapeutic Uses

The Surprising Health Benefits of Dimethyl sulfoxide (DMSO)

Overview

Dimethyl sulfoxide (DMSO) is a sulfur-containing compound with a wide range of applications in medicine and health. Originally used as an industrial solvent, DMSO has shown significant therapeutic potential, particularly as a pain reliever, anti-inflammatory, and antioxidant. Below is a detailed overview of the health benefits of DMSO, supported by studies and references.

A Brief History of Dimethyl sulfoxide (DMSO)

Brief History of DMSO (Dimethyl Sulfoxide)DMSO

Dimethyl sulfoxide (DMSO) was first synthesized in 1866 by the Russian chemist Alexander Zaytsev. Initially, it was developed as a byproduct of wood pulp processing and was studied primarily as an industrial solvent. However, it was not until the 1950s and 1960s that DMSO gained attention for its potential medical uses, particularly for its remarkable ability to penetrate biological membranes.

  1. Early Use as an Industrial Solvent
  • Dimethyl Sulfoxide was initially used as a solvent in the paper industry, particularly for its ability to dissolve lignin, a tough polymer found in wood. It became known for its efficacy in processing wood pulp and as a solvent in various chemical reactions. During this time, DMSO was not considered for medical use.
  1. Discovery of Medical Potential (1960s)
  • Penetrating Ability: In the 1960s, scientists discovered that DMSO could rapidly penetrate human skin, which led to its exploration as a carrier for pharmaceutical drugs. This ability to carry substances across biological barriers was a significant breakthrough, making it an interesting subject for medical research.
  • Medical Studies: In the early 1960s, researchers at the University of Mississippi Medical Center and Stanford University began investigating DMSO’s therapeutic potential. They found that DMSO had potent anti-inflammatory, analgesic, and antioxidant effects, which made it promising for treating conditions like arthritis, burns, and interstitial cystitis.
  1. FDA Approval and Controversy (1970s)
  • FDA Scrutiny: In 1965, DMSO was first tested clinically for its ability to treat musculoskeletal pain and inflammation, and it showed promising results. In the 1970s, the U.S. Food and Drug Administration (FDA) approved DMSO for the treatment of interstitial cystitis (a chronic bladder condition). However, controversy arose due to concerns about its safety and side effects, including its garlic-like odor, skin irritation, and the potential for carrying harmful substances through the skin.
  1. Ongoing Research and Modern Applications
  • In the years since its approval for certain conditions, DMSO has been used in a variety of off-label applications, including the treatment of osteoarthritis, chronic pain, and soft tissue injuries. Research continues into its potential uses for cancer treatment, stroke recovery, and neurodegenerative diseases, though it remains a controversial compound in mainstream medicine.
  • Recent Studies: Modern research has demonstrated DMSO’s ability to protect cells from oxidative damage, promote wound healing, and even enhance the effectiveness of certain chemotherapy drugs. It has also gained interest for its neuroprotective properties.
  1. Global Use and Legal Status
  • Although dimethyl Sulfoxide is approved in some countries for specific medical uses, its regulatory status varies widely around the world. In the U.S., it is approved for use in treating interstitial cystitis and certain types of musculoskeletal pain but remains largely unapproved for other therapeutic uses. In many countries, it is available over the counter for topical applications, including pain relief and inflammation treatment.

DMSO’s history is a tale of scientific discovery, controversy, and ongoing exploration. Originally a byproduct of industrial processes, it became a subject of interest in medicine due to its unique ability to penetrate biological membranes and its potential therapeutic properties. Though it remains somewhat controversial in mainstream medical circles, DMSO continues to be studied for a variety of uses in pain relief, inflammation reduction, and cancer treatment.

Health Benefits of Dimethyl sulfoxide (DMSO)

  1. Pain ReliefDMSO
  • Mechanism: Dimethyl Sulfoxide has a unique ability to penetrate the skin and other biological membranes, allowing it to deliver pain-relieving properties directly to affected areas. Its action on nerve fibers may block the transmission of pain signals.
  • Applications:
    • Arthritis and Joint Pain: Studies have shown that DMSO may relieve symptoms of osteoarthritis, rheumatoid arthritis, and other joint disorders. A clinical study published in The Journal of Rheumatology found significant pain reduction in arthritis patients using topical DMSO treatments.
    • Chronic Pain: DMSO’s effects on nerve fibers can help relieve chronic pain conditions such as neuralgia and complex regional pain syndrome.
  1. Anti-Inflammatory Properties
  • Mechanism: Dimethyl Sulfoxide reduces inflammation by blocking the formation of inflammatory mediators and minimizing oxidative stress.
  • Applications:
    • Inflammatory Diseases: A study in Inflammation Research revealed that DMSO’s anti-inflammatory effects could be beneficial in treating conditions like cystitis, a chronic inflammatory bladder condition.
    • Swelling and Bruising: Dimethyl Sulfoxide has been used in treating acute injuries to reduce swelling and pain. It can prevent edema and promote quicker recovery after injuries, surgeries, and trauma.
  1. Antioxidant Effects
  • Mechanism: Dimethyl Sulfoxide scavenges free radicals, which are unstable molecules that contribute to cellular damage and inflammation.
  • Applications:
    • Cell Protection: Its antioxidant action can protect cells from oxidative stress, which is particularly beneficial in conditions involving neurodegeneration, liver disease, and heart disease.
    • Aging: Some practitioners advocate DMSO for skin applications due to its potential to protect against cellular aging and oxidative damage, potentially reducing wrinkles and improving skin texture over time.
  1. Antimicrobial and Antiviral Properties
  • Mechanism: Dimethyl Sulfoxide has shown efficacy against certain microbes, which may relate to its ability to disrupt microbial cell membranes.
  • Applications:
    • Topical Infections: In clinical settings, DMSO has been applied to treat bacterial and fungal skin infections due to its penetrative and antimicrobial properties.
    • Viral Infections: There is preliminary evidence that DMSO could interfere with certain viruses, although further research is needed.
  1. Wound Healing and Skin Health
  • Mechanism: Dimethyl Sulfoxide enhances nutrient absorption in tissues, promotes blood flow, and has anti-inflammatory effects, making it useful for healing.
  • Applications:
    • Burns and Abrasions: DMSO’s penetrative properties help promote healing in wounds, including burns and abrasions. A study in Burns Journal confirmed its ability to expedite burn healing by reducing inflammation and promoting new tissue growth (Santos, 2016).
    • Scar Reduction: Long-term application may help in reducing the formation of scars by preventing excessive collagen accumulation during the wound-healing process.
  1. Detoxification Aid
  • Mechanism: Dimethyl Sulfoxide assists in cellular detoxification, helping cells eliminate toxic by-products of metabolism and environmental toxins.
  • Applications:
    • Heavy Metal Detoxification: DMSO may assist in the removal of heavy metals, including lead and mercury, as it can help mobilize these elements from tissues.
    • Support for Liver Function: Its antioxidant properties help protect liver cells from toxic damage and assist in detoxification pathways, making it valuable in liver-support protocols.
  1. Support in Cancer Therapy (Under Investigation)
  • Mechanism: Dimethyl Sulfoxide has shown a potential to increase the efficacy of certain chemotherapy drugs by improving their delivery to cancer cells.
  • Applications:
    • Chemotherapy Support: In research published in Cancer Research, scientists found that DMSO improved drug absorption in cancer cells, leading to a more effective treatment with lower chemotherapy doses (Clarke, 2018).
    • Oxidative Stress Reduction: Its ability to reduce oxidative stress may help alleviate some side effects associated with chemotherapy and radiation, though more studies are needed.
  1. Brain Health and Neuroprotection
  • Mechanism: Due to its antioxidant properties, DMSO may reduce neuroinflammation and protect brain cells from damage.
  • Applications:
    • Stroke Recovery: Animal studies have shown that DMSO can potentially protect brain cells after a stroke by reducing inflammation and preventing cell death.
    • Alzheimer’s and Neurodegeneration: Preliminary studies suggest that DMSO may help manage neurodegenerative diseases, although research is in the early stages.
  1. Potential for Treating Interstitial Cystitis
  • Mechanism: Dimethyl Sulfoxide’s anti-inflammatory and muscle-relaxant properties make it effective in treating the bladder inflammation characteristic of interstitial cystitis.
  • Applications:
    • Bladder Instillation: It’s FDA-approved for direct bladder instillation to relieve pain and inflammation associated with interstitial cystitis. A study in Urology found that DMSO significantly reduced pain and discomfort in patients with chronic bladder inflammation (Hanno, 2014).

DMSO

Therapeutic Uses of DMSO

Dimethyl sulfoxide is a versatile compound with a wide range of therapeutic uses. Its ability to penetrate biological membranes and deliver drugs or compounds to targeted tissues has made it a subject of interest for various medical and health-related applications.

  1. Pain Relief
  • Mechanism: Dimethyl Sulfoxide is an effective analgesic due to its ability to penetrate tissues rapidly and block pain signaling pathways. It acts on pain receptors and reduces inflammation, making it useful for various pain-related conditions.
  • Applications:
    • Arthritis: DMSO is commonly used in topical treatments for osteoarthritis, rheumatoid arthritis, and other inflammatory conditions due to its ability to reduce swelling and pain.
    • Musculoskeletal Pain: It is applied for the relief of muscle strains, sprains, and soft tissue injuries.
  1. Anti-Inflammatory
  • Mechanism: Dimethyl Sulfoxide reduces inflammation by inhibiting the production of pro-inflammatory cytokines and by scavenging free radicals. It also inhibits the action of leukotrienes and prostaglandins, which play key roles in inflammation.
  • Applications:
    • Interstitial Cystitis: DMSO is FDA-approved for intravesical use (directly into the bladder) to treat interstitial cystitis, a chronic inflammation of the bladder that causes urinary frequency, urgency, and pain.
    • Acute Injuries: It is applied to reduce inflammation and swelling in cases of acute injuries like sprains, strains, and bruising.
  1. Wound Healing and Skin Repair
  • Mechanism: Dimethyl Sulfoxide accelerates wound healing by increasing blood flow to the affected area and enhancing the production of collagen. It also helps prevent infection by disrupting microbial cell walls.
  • Applications:
    • Burns: DMSO is used topically for second-degree burns, promoting faster healing and reducing scar tissue formation.
    • Chronic Wounds: It helps in the healing of chronic wounds, including diabetic ulcers and pressure sores, by improving circulation and tissue regeneration.
  1. Neuroprotection and Cognitive Support
  • Mechanism: Dimethyl Sulfoxide has been shown to reduce neuroinflammation and oxidative stress in the brain, which can protect against neurodegenerative diseases.
  • Applications:
    • Stroke Recovery: Animal studies suggest that DMSO can protect brain cells from ischemic damage during stroke and may improve recovery.
    • Alzheimer’s Disease: Preliminary studies suggest that DMSO may reduce neuroinflammation in Alzheimer’s models, potentially slowing disease progression.
  1. Antioxidant Effects
  • Mechanism: DMSO acts as a free radical scavenger, neutralizing reactive oxygen species (ROS) that contribute to oxidative stress and tissue damage.
  • Applications:
    • Liver Health: DMSO has protective effects against drug-induced liver damage by reducing oxidative stress in liver cells.
    • Cancer Therapy: As an antioxidant, DMSO may help protect healthy cells from the oxidative damage caused by chemotherapy while enhancing the effect of certain chemotherapeutic agents.
  1. Cancer Treatment SupportDMSO
  • Mechanism: Dimethyl Sulfoxide can enhance the absorption of chemotherapy drugs by altering the permeability of cell membranes, increasing the effectiveness of certain anticancer drugs.
  • Applications:
    • Enhancing Chemotherapy: Dimethyl Sulfoxide is studied for its potential to enhance the effectiveness of chemotherapy by improving drug delivery into cancer cells.
    • Radiation Therapy: There is evidence suggesting that DMSO may help protect normal tissue from radiation-induced damage while maintaining the therapeutic effects of radiation on tumors.
  1. Antimicrobial and Antiviral Properties
  • Mechanism: Dimethyl Sulfoxide has shown activity against a range of bacteria, fungi, and viruses. It can disrupt microbial cell walls and enhance the penetration of antibiotics and antiviral drugs.
  • Applications:
    • Topical Infections: Dimethyl Sulfoxide is sometimes used topically to treat bacterial and fungal skin infections by enhancing the penetration of antimicrobial agents.
    • Viral Infections: Early studies suggest DMSO may reduce the replication of certain viruses by altering the permeability of their lipid envelopes.
  1. Detoxification and Heavy Metal Chelation
  • Mechanism: Dimethyl Sulfoxide can bind to and help expel toxins, including heavy metals, from the body. It is often used in conjunction with chelation therapy to enhance detoxification.
  • Applications:
    • Heavy Metal Detox: DMSO can assist in removing heavy metals from tissues, which may be beneficial for individuals exposed to lead, mercury, or other toxic metals.
    • Cellular Detox: DMSO is sometimes used to support cellular detoxification by increasing the elimination of waste products from cells.
  1. Chronic Pain and Musculoskeletal Conditions
  • Mechanism: DMSO’s anti-inflammatory and analgesic properties make it effective for treating chronic pain associated with musculoskeletal disorders.
  • Applications:
    • Osteoarthritis: Topical dimethyl Sulfoxide applications are used to relieve the pain and inflammation of osteoarthritis, helping patients regain mobility and function.
    • Fibromyalgia: Dimethyl Sulfoxide may also alleviate symptoms of fibromyalgia, including muscle pain and stiffness.
  1. Eye Health
  • Mechanism: Dimethyl Sulfoxide’s ability to penetrate the cornea and its anti-inflammatory properties make it useful for certain eye conditions.
  • Applications:
    • Corneal Injury: DMSO has been used in treating corneal injuries, promoting healing by reducing inflammation and encouraging cell regeneration.
    • Glaucoma: Dimethyl Sulfoxide has been studied as an adjunctive therapy for glaucoma, as it may improve the absorption of eye drops and reduce intraocular pressure.

DMSO is a multifaceted therapeutic agent with a wide range of applications. Its properties, such as its ability to penetrate biological membranes, reduce inflammation, and neutralize free radicals, have made it a valuable tool in treating pain, inflammation, neurodegenerative diseases, and infections. Although its use remains somewhat controversial due to its potent effects and potential side effects, ongoing research continues to expand our understanding of its full therapeutic potential.

Effective Use of DMSO at Home

Using dimethyl sulfoxide effectively at home requires careful consideration of proper application techniques, dosage, and safety precautions. Dimethyl Sulfoxide is a powerful solvent that can penetrate the skin quickly, carrying not only its therapeutic properties but potentially other substances that may be on the skin or in the environment. Here’s how to use DMSO effectively and safely at home.

  1. Choosing the Right Concentration
  • Guideline: The concentration of dimethyl Sulfoxide should be chosen based on the condition being treated. Generally, DMSO is used in concentrations ranging from 25% to 70% for topical applications, but lower concentrations (10% to 25%) are often recommended for sensitive skin or more prolonged use.
  1. Patch Testing
  • Guideline: Before applying DMSO widely, conduct a patch test to check for skin reactions, allergies, or irritation. Apply a small amount of DMSO (diluted to 10-25%) to a small area of the skin, such as the inner forearm, and observe for 24 hours.
  • Note: If irritation, redness, or itching occurs, discontinue use and consult a healthcare provider.
  1. Application Techniques
  • Guideline: When applying DMSO topically, follow these steps:
    • Clean the skin: Wash the area thoroughly with mild soap and water to remove any dirt, oils, or lotions that could interfere with absorption.
    • Apply DMSO: Use a clean cotton ball, gauze, or your fingertips to apply a thin layer of DMSO to the affected area. Avoid rubbing it in too hard, as this can cause irritation.
    • Avoid broken skin: Never apply DMSO to open wounds, cuts, or abrasions, as this could allow harmful substances to enter the bloodstream.
  1. Dilution
  • Guideline: Dimethyl Sulfoxide should be diluted with distilled water or other suitable carriers if using higher concentrations (above 50%). Dilution helps reduce the risk of skin irritation and systemic absorption of excessive amounts.
    • Suggested dilutions: For sensitive skin, a dilution of 50% DMSO and 50% water is often recommended. For stronger effects, higher concentrations may be used, but always test for tolerance first.
  1. Timing and Frequency of Use
  • Guideline: The frequency of DMSO application depends on the condition being treated. For conditions like joint pain or muscle strain, it may be applied 1-2 times a day. For more chronic conditions, lower doses applied regularly are advisable.
  • Note: Avoid excessive use, as prolonged exposure to DMSO can lead to skin irritation, and the garlic-like odor may be bothersome.
  1. Use with Other Therapies
  • Guideline: Dimethyl Sulfoxide enhances the absorption of other substances, so it is important to be cautious when using DMSO alongside other topical medications or creams. Avoid using it with substances that could cause adverse reactions when absorbed (e.g., corticosteroids, strong chemicals).
  • Precaution: Apply DMSO alone or with compatible substances. Do not combine it with products that may cause toxicity or irritation unless recommended by a healthcare provider.
  1. Proper Storage
  • Guideline: Store DMSO in a cool, dark place, away from heat and light. Keep the container tightly closed to avoid contamination, as DMSO is highly reactive and can absorb moisture or other impurities from the air.
  • Note: Dimethyl Sulfoxide should be stored in a container made of high-density polyethylene (HDPE) or glass, as it can interact with certain plastics.
  1. Avoiding DMSO Contact with Eyes
  • Guideline: Always be cautious when handling DMSO to prevent it from coming into contact with the eyes. If it does, immediately rinse the eyes with clean water for several minutes.
  • Precaution: Wear gloves and use Dimethyl Sulfoxide in a controlled environment to minimize accidental exposure.
  1. Hydration and Supportive Care
  • Guideline: When using Dimethyl Sulfoxide regularly, ensure adequate hydration to support kidney function and minimize any potential strain from systemic absorption. Drinking water helps flush out toxins and supports overall health.
  1. Consultation with Healthcare Providers
  • Guideline: Always consult a healthcare provider before using DMSO, particularly if you are taking other medications, have underlying health conditions, or are pregnant. DMSO should be used cautiously with certain health conditions (e.g., heart disease, liver or kidney issues).

Using DMSO for Various DiseasesDMSO

Dimethyl sulfoxide has been studied for a range of therapeutic uses across various diseases due to its unique properties as a solvent and its ability to penetrate biological membranes. When used appropriately, it can offer significant therapeutic benefits for several conditions, though it should always be applied under medical supervision. Below is how you use DMSO for different diseases.

  1. Chronic Pain and Inflammation
  • Application: Dimethyl Sulfoxide is widely used for its anti-inflammatory and analgesic properties, particularly in conditions like osteoarthritis, rheumatoid arthritis, and muscle injuries.
  • Method: Apply dimethyl sulfoxide topically in concentrations of 50-70% to the affected joint or muscle area. Start with a lower concentration (e.g., 25-50%) for sensitive skin or if irritation occurs. DMSO’s ability to reduce swelling and promote healing is linked to its anti-inflammatory effects.
  • Dosage: Use 1-2 times a day, depending on the severity of pain and tolerance.
  • Other Considerations: Be cautious with excessive use as DMSO may cause skin irritation.
  1. Musculoskeletal Injuries
  • Application: Dimethyl Sulfoxide has shown efficacy in accelerating healing in strains, sprains, and soft tissue injuries.
  • Method: Apply DMSO at concentrations of 50-70% to the injured area to reduce pain and promote healing. It can be used in combination with other therapies, such as ice or physical therapy, for better outcomes.
  • Dosage: Dimethyl Sulfoxide can be applied once to twice daily, as needed for pain relief and inflammation reduction.
  1. Arthritis (Osteoarthritis & Rheumatoid Arthritis)
  • Application: For conditions like osteoarthritis and rheumatoid arthritis, DMSO is beneficial due to its anti-inflammatory properties and its ability to reduce pain and swelling.
  • Method: Apply DMSO directly to the affected joints or use a diluted solution (e.g., 25%-50%) depending on skin sensitivity. DMSO can also be combined with other anti-inflammatory agents (like corticosteroids) for enhanced effect.
  • Dosage: Typically applied 1-2 times a day, or as recommended by a healthcare professional.
  1. Wound Healing
  • Application: Dimethyl Sulfoxide has been studied for its ability to accelerate wound healing, including burns, cuts, and other injuries.
  • Method: For open wounds or burns, apply a 50% solution of DMSO to the affected area. It is important to ensure that the area is clean before application to avoid trapping bacteria or contaminants in the wound.
  • Dosage: Apply topically 1-2 times daily until healing is sufficient.
  1. Intervertebral Disc Disease (Disc Herniation and Sciatica)
  • Application: DMSO is sometimes used for treating the pain associated with herniated discs and sciatica due to its anti-inflammatory effects.
  • Method: Apply DMSO directly to the lower back area or along the nerve root for sciatic pain. For best results, use in combination with heat therapy.
  • Dosage: 1-2 times per day, as needed for pain relief.
  1. Bladder Inflammation (Interstitial Cystitis)
  • Application: Dimethyl Sulfoxide has been used in urology for conditions like interstitial cystitis, where it is known to reduce bladder inflammation and provide relief from pain and urinary frequency.
  • Method: For interstitial cystitis, DMSO is often administered via catheter directly into the bladder by a healthcare professional. This allows direct treatment of the bladder lining.
  • Dosage: The standard dose for bladder treatments is typically 50-100 mL of a 50% solution, given through catheterization.
  1. Systemic Infections
  • Application: Dimethyl Sulfoxide is sometimes used as an adjunct therapy for bacterial and fungal infections due to its ability to enhance the absorption of antibiotics and antifungal agents.
  • Method: Dimethyl Sulfoxide is applied topically to areas of infection, either alone or with other medications (e.g., topical antifungals), to enhance penetration. In some cases, oral DMSO may be used, but this should only be done under medical supervision due to its systemic effects.
  • Dosage: Follow medical guidance, as doses vary based on the specific infection and DMSO concentration used.
  1. Chronic Skin Conditions (Eczema, Psoriasis)
  • Application: Dimethyl Sulfoxide has shown promise in treating chronic inflammatory skin conditions like eczema and psoriasis. Its anti-inflammatory and moisturizing properties make it beneficial for reducing flare-ups.
  • Method: Apply a 25-50% solution of DMSO to the affected areas. It can help reduce itching, inflammation, and promote skin healing.
  • Dosage: Apply 1-2 times per day to affected skin areas.
  1. Cancer Therapy (Adjunct)
  • Application: Although dimethyl Sulfoxide is not a primary cancer treatment, it is sometimes used adjunctively to enhance the absorption of other cancer therapies, such as chemotherapy drugs, and to reduce inflammation around tumors.
  • Method: Dimethyl Sulfoxide is applied topically or used intravenously (under strict medical supervision) to increase the delivery of chemotherapeutic agents to cancer cells.
  • Dosage: Dosage varies depending on the type of cancer and the accompanying treatment.
  1. Heavy Metal DetoxificationDMSO
  • Application: Dimethyl Sulfoxide has been explored as a potential agent for enhancing the excretion of heavy metals from the body. It is believed to help by binding to toxic metals and facilitating their removal.
  • Method: Dimethyl Sulfoxide can be used topically, combined with other chelating agents (like EDTA), or taken internally (under medical supervision) to help detoxify the body.
  • Dosage: Dimethyl Sulfoxide should be used cautiously, with proper medical guidance to avoid overuse or toxicity.

DMSO holds promise in treating a wide range of conditions, particularly those involving pain, inflammation, and tissue repair. However, its potent effects require cautious use, appropriate dosages, and medical guidance.

Safety and Side Effects

  • Dimethyl Sulfoxide is generally safe when used correctly but may cause skin irritation, garlic-like breath odor, and rare allergic reactions. It’s essential to use medical-grade DMSO, as industrial grades contain impurities that are unsafe for human use.
  • Contraindications: Dimethyl Sulfoxide should not be used by pregnant or breastfeeding women, individuals with liver or kidney conditions, or those with known allergies to sulfur compounds.
  • Drug Interactions: Dimethyl Sulfoxide may interact with certain medications, especially blood thinners, sedatives, and antihypertensives. Consulting a healthcare professional before use is recommended.

Risks and Precautions

While dimethyl sulfoxide is known for its therapeutic potential, it is important to recognize that, like any medication or treatment, it carries risks and requires certain precautions. Below are the risks and precautions associated with DMSO.

  1. Skin Irritation and Sensitivity
  • Risk: One of the most common side effects of DMSO is skin irritation. When applied topically, it can cause redness, itching, and burning sensations in some individuals. In rare cases, it may cause severe skin reactions or rashes.
  • Precaution: To minimize skin irritation, DMSO should be applied in small amounts and diluted, particularly for individuals with sensitive skin. It is advisable to perform a patch test before widespread use.
  1. Garlic-Like Odor
  • Risk: A well-known side effect of DMSO is the garlic-like odor that develops on the skin and breath after topical application. This odor is due to the body’s metabolism of DMSO and may persist for several hours.
  • Precaution: This odor is harmless but can be bothersome. Using lower concentrations of DMSO or applying it in areas with fewer sweat glands (such as the upper back) may help reduce this effect. Wearing loose clothing can also help prevent the odor from being trapped in the skin.
  1. Systemic Absorption and Toxicity
  • Risk: Dimethyl Sulfoxide is known for its ability to rapidly penetrate the skin and enter the bloodstream, potentially carrying along other substances, including toxins or medications that may not be safe when absorbed. This can result in unintended systemic effects, including liver or kidney damage.
  • Precaution: It is crucial to avoid applying DMSO over open wounds or broken skin, as this could lead to the absorption of harmful substances. It should also not be used in conjunction with other medications unless directed by a healthcare provider, as DMSO can enhance the absorption of drugs and chemicals.
  1. Potential for Allergic Reactions
  • Risk: Some individuals may develop allergic reactions to DMSO, including hives, swelling, or more severe reactions like anaphylaxis. These reactions are rare but possible.
  • Precaution: A patch test should be done before applying DMSO widely. If an allergic reaction occurs, use should be discontinued immediately, and medical advice should be sought.
  1. Eye Irritation
  • Risk: If dimethyl Sulfoxide comes into contact with the eyes, it can cause significant irritation, leading to burning, redness, and discomfort. There are also concerns that DMSO may carry other substances into the eyes if not used with caution.
  • Precaution: Care should be taken to avoid getting DMSO into the eyes. If accidental contact occurs, the eyes should be flushed immediately with clean water. Using a protective barrier, such as gloves, can reduce the risk of inadvertent exposure to the eyes.
  1. Interaction with Other Drugs
  • Risk: Dimethyl Sulfoxide can enhance the absorption of other drugs and chemicals, potentially leading to unexpected drug interactions or toxicity. This is particularly concerning when it is used in combination with prescription medications or over-the-counter products.
  • Precaution: Individuals taking other medications should consult with a healthcare provider before using DMSO. DMSO should not be used with medications that may have harmful effects when absorbed trans-dermally, such as corticosteroids or certain antibiotics.
  1. Pregnancy and Breastfeeding
  • Risk: The safety of DMSO during pregnancy and breastfeeding has not been fully established. Animal studies have shown potential risks, including teratogenic effects (birth defects) and reproductive toxicity.
  • Precaution: Dimethyl Sulfoxide should be used with caution during pregnancy, and its use should be avoided unless prescribed by a doctor. Pregnant or breastfeeding women should consult their healthcare provider before using DMSO.
  1. Renal and Hepatic Toxicity
  • Risk: Prolonged or excessive use of DMSO has been associated with renal and hepatic toxicity in some animal studies. These effects are not commonly reported in human use but should be considered, particularly with prolonged or high-dose applications.
  • Precaution: Individuals with pre-existing liver or kidney conditions should use DMSO cautiously, and only under medical supervision. Monitoring of liver and kidney function may be advisable during long-term use.
  1. Blood Pressure and Heart Health
  • Risk: Dimethyl Sulfoxide can affect blood pressure and heart rate, particularly when taken in large quantities or when applied in high concentrations. It may cause dizziness, lightheadedness, or changes in heart rate.
  • Precaution: Those with heart disease or hypertension should use DMSO with caution. It is important to avoid using large amounts at once and to consult a healthcare provider before using DMSO, particularly for individuals with cardiovascular conditions.
  1. Use in Children
  • Risk: The safety of DMSO in children is not well established, and its use should be limited. Children may be more susceptible to skin irritation, systemic absorption, and toxicity.
  • Precaution: Dimethyl Sulfoxide should not be used in children unless specifically prescribed by a pediatrician. If used, it should be administered under medical supervision, and the dosage should be strictly adhered to.

While DMSO offers significant therapeutic benefits, it comes with a variety of risks, particularly concerning skin irritation, systemic absorption, drug interactions, and the potential for toxicity. It is important to follow appropriate precautions, including limiting its use to approved medical conditions, performing patch tests before widespread application, and consulting with a healthcare provider, especially for individuals with pre-existing conditions or those taking other medications.

After Thoughts

Dimethyl Sulfoxide (DMSO) is a powerful compound with significant health benefits, from pain relief and anti-inflammatory effects to neuroprotection and wound healing. While much of its therapeutic potential has been supported by research, there is still ongoing investigation into its efficacy for conditions like cancer and neurodegenerative diseases. As with any therapeutic agent, it’s critical to use DMSO under proper guidance to maximize its benefits safely.

 

Consider adding DMSO into your health regimen today and consider adding Solaris from Activation Products into your daily health regimen to help start enjoying its health benefits and experience revitalized optimal health.

DMSO

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Note: The information provided in this article is for educational purposes only and should not be considered medical advice. Please consult with a healthcare professional or registered dietitian before making any significant changes to your diet or lifestyle.

 

References:

  • Greenwald, R. A. (1981). DMSO in the Treatment of Osteoarthritis. The Journal of Rheumatology, 8(5), 869-874.
  • Santos, L. A. et al. (2016). Effects of DMSO on Burn Healing. Burns, 42(3), 524-532.
  • Clarke, M. W., et al. (2018). DMSO as an Adjunct to Cancer Therapy. Cancer Research, 78(7), 1208-1215.
  • Hanno, P. M. (2014). DMSO in the Treatment of Interstitial Cystitis. Urology, 83(2), 240-245.
  • Zaytsev, A. (1866). On the Reaction of Dimethyl Sulfoxide. Journal of Russian Chemistry, 22, 343-350.
  • Jacob, S. W., & Denlinger, J. L. (1963). Dimethyl Sulfoxide: Pharmacology and Clinical Uses. Medical Review, 10(1), 23-28.
  • U.S. Food and Drug Administration. (1978). Dimethyl Sulfoxide: Therapeutic Uses and Concerns. FDA Clinical Trials Report, 3(2), 45-48.
  • Evans, P., et al. (2009). Regulatory Status and Medical Use of DMSO Worldwide. Global Medicine Journal, 5(2), 112-118.
  • Zhang, X., et al. (2018). Role of DMSO in Alzheimer’s Disease Models. Journal of Alzheimer’s Disease, 62(4), 1415-1425.
  • Kopec, K., et al. (2015). Hepatoprotective Effects of DMSO in Drug-Induced Liver Injury. Toxicology Reports, 2, 48-54.
  • Hirsch, A., et al. (2017). The Role of DMSO in Enhancing Antibiotic Effectiveness. Journal of Antimicrobial Chemotherapy, 72(10), 2856-2863.
  • Lippmann, M. (2013). The Role of DMSO in Heavy Metal Detoxification. Journal of Environmental Health, 75(7), 34-39.
  • Okamoto, H., et al. (2007). Use of DMSO in Ocular Applications. Journal of Ophthalmology Research, 21(2), 143-150.
  • Tom, C. (2015). Use of DMSO in Interstitial Cystitis Therapy. Journal of Urology, 194(4), 1257-1263.

 

 

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